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Vedolizumab is given as an intravenous (IV) infusion – that is, through a drip into a vein in your arm. It cannot be given as tablets because your digestive system would destroy it.
Infliximab infusions are usually given in hospital by a trained member of staff. You will probably be treated as a day outpatient (unless you are already in the hospital) and will be able to have the infusion while sitting in a chair, so you won’t have to undress, get into bed or stay overnight.
The initial infusion itself usually takes from about a half of a hour to an hour, but subsequent infusions may be given faster depending on the local practice. If you have previously had an infusion reaction, the infusion time may be increased in order to decrease the risk of another reaction. You may be given paracetamol, antihistamine or hydrocortisone just before the infusion, to minimize the risk of side effects.
You will be closely observed by your medical team during the infusion and afterward to make sure that you do not develop an allergic reaction. Different hospitals may do this differently, and some hospitals allow patients to go home as soon as the infusion has finished.
The recommended dosage of ENTYVIO in adults with UC and CD is 300 mg administered by intravenous infusion at zero, two and six weeks and then every eight weeks thereafter.
Most people with IBD have an initial infusion followed by another infusion two weeks later and a third after six weeks. If you respond well to the treatment, it is likely you will be put onto a maintenance programme of an infusion every eight weeks. If there has been no improvement by week 14, then vedolizumab is unlikely to be effective for you and an alternative treatment will be sought.
Copyright 2024 IBD Clinic.