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There is some evidence that combining infliximab with an immunosuppressant drug such as Azathioprine or Methotrexate may also be helpful for some people with IBD. The evidence is less for Methotrexate, but Azathioprine is thought to reduce the formation of antibodies to Infliximab, reduce the likelihood of an infusion reaction, and increase the chance of remission.
Also, because Azathioprine may take 3-6 months to start working, it can be useful if patients start on it while they are on Infliximab so that it has had a chance to start to work if Infliximab is stopped.
However, some studies have suggested that combination therapies may also increase the risk of side effects, including infections and some types of cancer. Also, some studies do not show so much evidence for their combined use. Your doctor should explain this to you, so that you can agree what is the best treatment option in your circumstances. Whether you are taking infliximab on its own or in combination with an immunosuppressant, your doctor will assess your progress every 12 months to decide whether you are still on the best treatment option for you.